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KMID : 0882420120830060752
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Korean Journal of Medicine
2012 Volume.83 No. 6 p.752 ~ p.756
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A Case of Primary Gastric ALK-Positive Anaplastic Large-Cell Lymphoma
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Chang Woo-Sung
Jeong Woo-Jin
Kang Gyoung-Hoon
Kwon Jang-Hoon
Hong Jong-Sam
Eom Dae-Woon
Cheon Gab-Jin
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Abstract
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Anaplastic large-cell lymphoma (ALCL) is a rare subgroup of non-Hodgkin’s lymphoma. Primary gastric ALCL is extremely rare. Patients with anaplastic lymphoma kinase (ALK)-positive primary systemic ALCL are known to have better overall survival than those with ALK-negative ALCL. We herein report a case of primary gastric ALK-positive anaplastic large-cell lymphoma. A 37-year-old woman presented with postprandial epigastric pain for 2 months. Endoscopic examination of the upper gastrointestinal tract showed multiple variably sized, round, elevated lesions with friable crater-erosion on the body and fundus. Pathologic examination revealed atypical large lymphoid cell infiltration in the lamina propria; the cells were positive for CD3, CD30, and ALK. We diagnosed the patient with ALCL. She underwent a cycle of chemotherapy with cyclophosphamide, adriamycin, vincristine, and prednisolone. However, she developed brain metastases. Despite two cycles of palliative chemotherapy with high-dose methotrexate for brain metastases, she died due to ALCL progression.
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KEYWORD
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Anaplastic lymphoma kinase, Lymphoma, Non-Hodgkin, Stomach neoplasm
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